Reversible inhibition of bacterial growth after specific inhibition of spermidine synthase by dicyclohexylamine

Reversible inhibition of bacterial growth after specific inhibition of spermidine synthase by dicyclohexylamine.

The effect of dicyclohexylamine on seven freshly isolated bacterial strains of mastitis pathogens was studied. Streptococcus uberis was the most sensitive strain investigated, since 5 mM-dicyclohexylamine totally arrested its growth and 1.25 mM of the drug caused 60% growth inhibition. The Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa strains were also sensitive to the drug...

Inhibition of spermidine synthase gene expression by transforming growth factor-beta 1 in hepatoma cells.

We screened genes responsive to transforming growth factor-beta (TGF-beta 1) protein in a human hepatoma cell line (Hep3B) using a PCR-mediated differential display technique, in order to investigate the mechanisms involved in TGF-beta-induced growth suppression. We found a gene that was down-regulated by TGF-beta 1 to be completely identical in an approx. 620 bp segment to the gene for the enz...

REOVIRUS GROWTH INHIBITION BY ROTAVIRUS FOLLOWING COINFECTION

Specific Aldosterone Synthase Inhibition

We have come to appreciate the many physiological and pathophysiological functions of adrenal steroid hormones in health and disease and the benefits and adverse effects of therapeutic manipulations. Glucocorticoids are an indispensable component in the treatment of inflammatory conditions. Blockade of the mineralocorticoid receptor (MR) with spironolactone is a long-established diuretic therap...

Inhibition of bacterial growth by leucine peptides.

In previous reports (I, 2), data were presented on the growth response of a leucineless mutant (strain 679-680)’ of Escherichia coli strain K-12 to various L-leucine peptides. Measurement of the extent of bacterial growth after 24 hours incubation showed that, at low concentrations, the peptides were almost as effective in the stimulation of growth as was L-leucine; at high concentrations, howe...